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Cancer Drug Resistance
Patients for whom standard anticancer treatments fail get reduced treatment effect from existing anticancer drugs or lack drug responsiveness due to anticancer drug resistance.
Cancer chooses a way to survive on its own by avoiding anticancer drugs such as viruses and develops a mechanism of continuous anticancer drug resistance, which eventually leads to the recurrence of cancer due to anticancer drug resistance.
There are two main mechanisms for developing anticancer drug resistance: intrinsic resistance, in which cancer cells do not show drug response due to the presence of resistant cancer cells from the initial administration of the drug; and acquired resistance, in which the cancer cells show anticancer drug resistance due to cancer cell proliferation by selecting a way to survive against the drug after the initial response through continuous administration of the drug.
- Cancer cell formation
- Death after anticancer treatment
- Acquisition of anticancer
treatment resistance
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Intrinsic Resistance
- Dead cancer cells Surviving cancer cells
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Reproduction of
surviving cancer cells
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Acquired Resistance
- Dead cancer cells Surviving cancer cells
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Reproduction of
surviving cancer cells
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- Genetic modification
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- Increased resistance-inducing proteins
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- Complex signaling system operation